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- Title
Anti-tumor activities and mechanism study of α-pinene derivative in vivo and in vitro.
- Authors
Ye, Lianbao; Zhang, Xiaoshun; Xu, Qiuxiang; Cai, Yongming; Gao, Wei; Chen, Weiqiang
- Abstract
In previous study, we designed novel α-pinene derivatives based on theories of bioalkylating agents using α-pinene as lead compound and patented these compounds, in which compound α-pinene derivative GY-1 (6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl-4-methylbenzenesulfonat) showed strongest inhibition on hepatoma carcinoma cell BEL-7402. In this study, we investigated effect of GY-1 on hepatocellular carcinoma in vitro and in vivo, and explored its mechanism of anti-hepatoma. The results showed that GY-1 showed good anti-liver cancer activity with the IC50 of 84.7 μmol/L in vitro, inhibited tumor growth in vivo with dose-dependent, and GY-1 could arrest the growth of hepatoma cells in the S phase and induced apoptosis in hepatoma cells, down-regulated the expression of C-myc, CDK2 and CyclinE, and up-regulate p53.
- Subjects
PINENE; HEPATOCELLULAR carcinoma; CELL growth; TUMOR growth; LEAD compounds; CELL cycle; DOWNREGULATION; P53 antioncogene
- Publication
Cancer Chemotherapy & Pharmacology, 2020, Vol 85, Issue 2, p367
- ISSN
0344-5704
- Publication type
journal article
- DOI
10.1007/s00280-019-03997-x