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- Title
Relationship between Prostate Inflammation and Periodontal Disease—A Systematic Review and Meta-Analysis.
- Authors
Ortíz de Urbina Comerón, Pablo; Zubizarreta-Macho, Álvaro; Lobo Galindo, Ana Belén; Montiel-Company, José María; Lorenzo-Gómez, María-Fernanda; Flores Fraile, Javier
- Abstract
The aim of this systematic review and meta-analysis was to analyze the association between periodontal disease and prostate inflammation with a null hypothesis stating that periodontal disease does not increase the incidence of prostate inflammation. Materials and methods: A systematic literature review and meta-analysis of longitudinal observational cohort and case-control studies that evaluated the odds ratio or hazard ratio and confidence interval was undertaken based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations (2020). A total of four databases were consulted in the literature search: PubMed-Medline, Scopus, Embase, and Web of Science. After eliminating duplicated articles and applying the inclusion criteria, seven articles were selected for the qualitative and quantitative analyses. Results: Four observational cohort studies and three observational cohort case-control studies were included in the meta-analysis. The four observational cohort studies were combined using the random effects model to estimate a hazard ratio of 1.32 with a confidence interval of 95% between 0.87 and 1.77. The meta-analysis presented high heterogeneity (Q test = 56.1; p value < 0.001; I2 = 94.9%). Moreover, the three observational case-control studies were combined using the random effects model to estimate an odds ratio of 1.62 with a confidence interval of 95% between 1.41 and 1.84. The meta-analysis presented high heterogeneity (Q test = 1.07; p value = 0.782; I2 = 0%). Conclusions: The incidence of periodontal disease does not increase the risk of the incidence of prostate inflammation.
- Subjects
PERIODONTAL disease; RANDOM effects model; PROSTATE; ODDS ratio; NULL hypothesis; PROSTATITIS
- Publication
Journal of Clinical Medicine, 2023, Vol 12, Issue 18, p6070
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm12186070