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- Title
Association between Non-HDL-C/HDL-C Ratio and Carotid Intima–Media Thickness in Post-Menopausal Women.
- Authors
Iannuzzi, Arcangelo; Giallauria, Francesco; Gentile, Marco; Rubba, Paolo; Covetti, Giuseppe; Bresciani, Alessandro; Aliberti, Emilio; Cuomo, Gilanluigi; Panico, Camilla; Tripaldella, Maria; Giusti, Maria Ausilia; Mattina, Alessandro; Iannuzzo, Gabriella
- Abstract
Atherogenic lipoproteins (particularly, very low-density lipoproteins, VLDL) are associated with subclinical atherosclerosis. The present study aims at evaluating whether routinely analysed lipid parameters are associated with carotid intima–media thickness, a proxy for subclinical atherosclerosis. Lipid parameters from 220 post-menopausal women undergoing ultrasound investigation of the carotid arteries were analysed. Forty-five percent of women showed subclinical atherosclerosis on carotid ultrasound. The mean carotid intima–media thickness was 1.26 ± 0.38 mm. The mean value of the non-HDL-C/HDL-C ratio was 3.1 ± 1.2. Univariate analysis showed a significant association between non-HDL-C/HDL-C ratio and intima–media thickness (r = 0.21, p = 0.001). After adjusting for cardiovascular risk factors (age, systolic blood pressure, smoking, body mass index Homeostasis model assessment: insulin resistance and high-sensitivity C-Reactive-Protein), multivariate analysis showed a significant association between non-HDL-C/HDL-C ratio and intima–media thickness (β = 0.039, p = 0.04). Logistic regression analysis showed that the highest tertile of the non-HDL-C/HDL-C ratio was associated with the presence of carotid plaques (OR = 3.47, p = 0.003). Finally, a strong correlation between non-HDL-C/HDL-C ratio and cholesterol bound to VLDL (r = 0.77, p < 0.001) has been found. Non-HDL-C/HDL-C ratio is associated with the presence of carotid atherosclerosis in post-menopausal women and is strongly correlated to VLDL-C levels.
- Subjects
CAROTID intima-media thickness; POSTMENOPAUSE; CAROTID artery; SYSTOLIC blood pressure; LOW density lipoproteins
- Publication
Journal of Clinical Medicine, 2022, Vol 11, Issue 1, p78
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm11010078