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- Title
Soluble C-Type Lectin-Like Receptor 2 Is a Biomarker for Disseminated Intravascular Coagulation.
- Authors
Yamamoto, Akitaka; Wada, Hideo; Ichkawa, Yuhuko; Tanaka, Motoko; Tashiro, Haruhiko; Shiraki, Katsuya; Shimpo, Hideto; Yamashita, Yoshiki; Mastumoto, Takeshi; Shimaoka, Motomu; Iba, Toshiaki; Suzuki-Inoue, Katsue
- Abstract
Disseminated intravascular coagulation (DIC) is induced by excess activation coagulation, and activated platelets are also involved in pathogenesis. Therefore, plasma levels of soluble C-type lectin-like receptor 2 (sCLEC-2), a new marker for platelet activation, can be expected as a marker of DIC in critically ill patients. Plasma levels of sCLEC-2 and D-dimer were measured using the STACIA system. Plasma sCLEC-2 and D-dimer levels were significantly higher in patients with underlying diseases of DIC than in those with unidentified clinical syndrome (UCS). Plasma sCLEC-2 levels were significantly higher in the patients with DIC and Pre-DIC than in those without DIC or Pre-DIC. Similarly, plasma D-dimer levels were also significantly higher in patients with DIC and Pre-DIC than in those without DIC or Pre-DIC. The plasma sCLEC-2 levels in all patients and those with a DIC score ≤ 4 were significantly higher in non-survivors than survivors. The plasma D-dimer levels in all patients, those with a DIC score ≥ 5 and those with a DIC score ≤ 4, were significantly higher in non-survivors than in survivors. The plasma sCLEC-2 is expected as a marker for DIC/Pre-DIC as well as the prognostic marker in critically ill patients.
- Subjects
BLOOD platelet activation; DISSEMINATED intravascular coagulation; BIOMARKERS; FIBRIN fragment D; CRITICALLY ill
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 13, p2860
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10132860