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- Title
Potentially Important Therapeutic Interactions between Antibiotics, and a Specially Engineered Emulsion Drug Vehicle Containing Krill-Oil-Based Phospholipids and Omega-3 Fatty Acids.
- Authors
Driscoll, David F.
- Abstract
The incidence of antimicrobial resistance (AMR) worldwide is increasing as the pipeline for the development of new chemotherapeutic entities is decreasing. Clearly, overexposure to antibiotics, including excessive dosing, is a key factor that fuels AMR. In fact, most of the new antibacterial agents under development are derivatives of existing classes of antibiotics. Novel approaches involving unique antimicrobial combinations, targets, and/or delivery systems are under intense investigation. An innovative combination of active pharmaceutical ingredients (APIs) consisting of antimicrobial drug(s), krill-oil-based phospholipids, and omega-3 fatty acid triglycerides, that may extend the therapeutic viability of currently effective antibiotics, at least until new chemical entities are introduced, is described.
- Subjects
ANTIBIOTICS; EMULSIONS (Pharmacy); DRUG carriers; PHOSPHOLIPIDS; OMEGA-3 fatty acids; DRUG efficacy; KRILL oil
- Publication
Antibiotics (2079-6382), 2018, Vol 7, Issue 1, p22
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics7010022