We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Role of Fc Gamma Receptors in Broad Protection against Influenza Viruses.
- Authors
Thulin, Natalie K.; Wang, Taia T.
- Abstract
Recent studies have revealed multiple roles for Fc gamma receptors (FcγRs) in broad immunity against influenza viruses. Activating FcγR pathways can be harnessed to confer protection mediated by non-neutralizing anti-HA IgGs and to increase the potency of broadly neutralizing anti-HA IgGs and of anti-NA IgGs. Separate FcγR pathways can be targeted to enhance the breadth of antibody responses elicited by seasonal influenza virus vaccines. Here, we review the current understanding of FcγR pathways in broad influenza immunity and suggest mechanisms to bypass FcγR signaling heterogeneity among people that arises from distinctions in structural repertoires of IgG Fc domains.
- Subjects
FC receptors; INFLUENZA prevention; INFLUENZA vaccines; INTRAVENOUS immunoglobulins; ONTOGENY
- Publication
Vaccines, 2018, Vol 6, Issue 3, p36
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines6030036