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- Title
RAMPing up knowledge of the translocon.
- Authors
VISMPAS, DIMITRIOS; FÖRSTER, FRIEDRICH
- Abstract
This article explores recent advancements in understanding the translocon, a molecular structure involved in protein insertion into the endoplasmic reticulum membrane. The researchers used cryo-electron microscopy techniques to study the ribosome-translocon complex and identified different intermediates of the translocon. They observed the opening of the Sec61 lateral gate, which aids in the insertion of transmembrane domains into the membrane. The article also discusses the discovery of two types of intermediates, one involving the presence of the second transmembrane rhodopsin domain and the other involving the binding of the transmembrane domain of RAMP4. The positioning of RAMP4 near the Sec61 lateral gate suggests its involvement in directing signal peptides. Further research is needed to validate these findings.
- Subjects
PROTEIN structure prediction; TRANSMEMBRANE domains; MOLECULAR structure; RIBOSOMAL proteins; MEMBRANE proteins; RIBOSOMES
- Publication
eLife, 2024, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.98548