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- Title
Metabolomics analysis reveals molecular linkages for the impact of vitamin D on childhood allergic airway diseases.
- Authors
Chang, Yu‐Ho; Yeh, Kuo‐Wei; Huang, Jing‐Long; Su, Kuan‐Wen; Tsai, Ming‐Han; Hua, Man‐Chin; Liao, Sui‐Ling; Lai, Shen‐Hao; Chen, Li‐Chen; Chiu, Chih‐Yung
- Abstract
Background: Several studies have reported the relevance between serum vitamin D and allergic immunoglobulin E (IgE) responses and atopic diseases. However, a metabolomics‐based approach to the impacts of vitamin D on allergic reactions remains unclear. Methods: A total of 111 children completed a 3‐year follow‐up were enrolled and classified based on longitudinal vitamin D status (≥ 30 ng/ml, n = 54; 20–29.9 ng/ml, n = 41; <20 ng/ml, n = 16). Urinary metabolomic profiling was performed using 1H‐Nuclear magnetic resonance (NMR) spectroscopy at age 3. Integrative analyses of their associations related to vitamin D levels, atopic indices, and allergies were performed, and their roles in functional metabolic pathways were also assessed. Results: Six and five metabolites were identified to be significantly associated with vitamin D status and atopic diseases, respectively (FDR‐adjusted p‐value <.05). A further correlation analysis revealed that vitamin D‐associated 3‐hydroxyisobutyric acid and glutamine were positively correlated with atopic disease‐associated succinic acid and alanine, respectively. Furthermore, hippuric acid was negatively correlated with atopic disease‐associated formic acid, which was positively correlated with vitamin D level (p <.01). Absolute eosinophil count (AEC) was positively correlated with serum D. pteronyssinus‐ and D. farinae‐specific IgE level (p <.01) but negatively correlated with vitamin D level (p <.05). Amino acid metabolisms were significantly associated with vitamin D related to childhood allergies. Conclusion: Integrative metabolomic analysis provides the link of vitamin D‐associated metabolites with the gut microbiome and immunoallergic reactions related to childhood allergies.
- Subjects
VITAMIN D; ALLERGIES; IMMUNOGLOBULIN E; AMINO acid metabolism; HIPPURIC acid; ATOPY
- Publication
Pediatric Allergy & Immunology, 2022, Vol 33, Issue 5, p1
- ISSN
0905-6157
- Publication type
Article
- DOI
10.1111/pai.13785