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- Title
Sero-epidemiological study of arbovirus infection following the 2015–2016 Zika virus outbreak in Cabo Verde.
- Authors
Ward, Daniel; Gomes, Ana Rita; Tetteh, Kevin K. A.; Sepúlveda, Nuno; Gomez, Lara Ferrero; Campino, Susana; Clark, Taane G.
- Abstract
In November 2015, cases of Zika virus infection were recorded in Cabo Verde (Africa), originating from Brazil. The outbreak subsided after seven months with 7580 suspected cases. We performed a serological survey (n = 431) in Praia, the capital city, 3 months after transmission ceased. Serum samples were screened for arbovirus antibodies using ELISA techniques and revealed seroconverted individuals with Zika (10.9%), dengue (1–4) (12.5%), yellow fever (0.2%) and chikungunya (2.6%) infections. Zika seropositivity was predominantly observed amongst females (70%). Using a logistic model, risk factors for increased odds of Zika seropositivity included age, self-reported Zika infection, and dengue seropositivity. Serological data from Zika and dengue virus assays were strongly correlated (Spearman's rs = 0.80), which reduced when using a double antigen binding ELISA (Spearman's rs = 0.54). Overall, our work improves an understanding of how Zika and other arboviruses have spread throughout the Cabo Verde population. It also demonstrates the utility of serological assay formats for outbreak investigations.
- Subjects
CABO Verde; CHIKUNGUNYA virus; ZIKA virus infections; ZIKA virus; DENGUE viruses; YELLOW fever; ARBOVIRUS diseases; SEROCONVERSION; ARBOVIRUSES
- Publication
Scientific Reports, 2022, Vol 12, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-022-16115-4