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- Title
Progress on biomarkers of idiopathic rapid eye movement sleep behavior disorder conversion to neurodegenerative diseases.
- Authors
ZHANG Xuan; XUE Rong
- Abstract
Idiopathic rapid eye movement sleep behavior disorde (iRBD) is a precursor symptom of neurodegenerative diseases, and most patients will convert to neurodegenerative diseases later in the disease. Reliable biological markers are of great significance for early identification of high-risk converters and predicting phenoconversion pattern. This paper reviews the research progress of biological markers in predicting conversion to neurodegenerative diseases in iRBD from clinical symptomology, neuroelectrophysiology, neuroimaging, body fluid, pathology and gene markers, in order to select patients suitable for disease modification therapy and delay the development of neurodegenerative diseases.
- Subjects
BODY fluid analysis; BIOMARKERS; PATIENT selection; RAPID eye movement sleep; ELECTROPHYSIOLOGY; GENETIC markers; PARASOMNIAS; NEURODEGENERATION; NEURORADIOLOGY; DISEASE risk factors; DISEASE complications
- Publication
Chinese Journal of Contemporary Neurology & Neurosurgery, 2023, Vol 23, Issue 8, p668
- ISSN
1672-6731
- Publication type
Article
- DOI
10.3969/j.issn.1672-6731.2023.08.003