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- Title
5-Arylidene N,N-dimethylbarbiturates as Urease Inhibitors.
- Authors
Khan, Khalid Mohammed; Khan, Momin; Khan, Ajmal; Perveen, Shahnaz; Naz, Farzana; Iqbal Choudhary, M.
- Abstract
Earlier 5-arylidene N,N-dimethylbarbiturates 1-24 were reported by our group as novel ant ioxidant, nevertheless, urease inhibitory act ivity of these compounds has not been invest igated at all. In the present study, compounds 1-24 were synthesized by the reaction of N,N-dimethylbarbituric acid with different aromat ic aldehydes, and screened for their in vitro urease inhibitory effects. Compound 7, was found to be most active urease inhibitor in the series. Nonetheless, compounds 11, 12, and 19 were also act ive against urease enzyme.
- Subjects
UREASE; BARBITURATE analysis; ANTIOXIDANT analysis; THIOUREA; ENZYME inhibitors
- Publication
Journal of the Chemical Society of Pakistan, 2014, Vol 36, Issue 3, p524
- ISSN
0253-5106
- Publication type
Article