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- Title
Angiogenesis and Inflammation in Peritoneal Dialysis: The Role of Adipocytes.
- Authors
Shi, Jun; Yu, Manshu; Sheng, Meixiao
- Abstract
Chronic inflammation and angiogenesis are the most common complications in patients undergoing maintenance peritoneal dialysis (PD), resulting in progressive peritoneum remolding and, eventually, utrafiltration failure. Contributing to the deeper tissue under the peritoneal membrane, adipocytes play a neglected role in this process. Some adipokines act as inflammatory and angiogenic promoters, while others have the opposite effects. Adipokines, together with inflammatory factors and other cytokines, modulate inflammation and neovascularization in a coordinated fashion. This review will also emphasize cellular regulators and their crosstalk in long-term PD. Understanding the molecular mechanism, targeting changes in adipocytes and regulating adipokine secretion will help extend therapeutic methods for preventing inflammation and angiogenesis in PD.
- Subjects
PERITONEAL dialysis; INFLAMMATION; NEOVASCULARIZATION; FAT cells; DIAGNOSIS
- Publication
Kidney & Blood Pressure Research, 2017, Vol 42, Issue 2, p209
- ISSN
1420-4096
- Publication type
Article
- DOI
10.1159/000476017