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- Title
Coexpression networks identify brain region-specific enhancer RNAs in the human brain.
- Authors
Yao, Pu; Lin, Peijie; Gokoolparsadh, Akira; Assareh, Amelia; Thang, Mike W C; Voineagu, Irina
- Abstract
Despite major progress in identifying enhancer regions on a genome-wide scale, the majority of available data are limited to model organisms and human transformed cell lines. We have identified a robust set of enhancer RNAs (eRNAs) expressed in the human brain and constructed networks assessing eRNA-gene coexpression interactions across human fetal brain and multiple adult brain regions. Our data identify brain region-specific eRNAs and show that enhancer regions expressing eRNAs are enriched for genetic variants associated with autism spectrum disorders.
- Subjects
RNA; BRAIN chemistry; GENE enhancers; CELL lines; SINGLE nucleotide polymorphisms; AUTISM spectrum disorders; GENE expression
- Publication
Nature Neuroscience, 2015, Vol 18, Issue 8, p1168
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.4063