We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Double-Filtration Plasmapheresis plus IFN for HCV-1b Patients with Non-Sustained Virological Response to Previous Combination Therapy: Early Viral Dynamics.
- Authors
Kim, Soo Ryang; Imoto, Susumu; Kudo, Masatoshi; Mita, Keiji; Taniguchi, Miyuki; Kim, Ke Ih; Sasase, Noriko; Shoji, Ikuo; Nagano-Fujii, Motoko; El-Shamy, Ahmed; Hotta, Hak; Nagai, Tomoyuki; Nagata, Yoshiaki; Hayashi, Yoshitake
- Abstract
Double-filtration plasmapheresis (DFPP) was approved in Japan in April 2008 for the retreatment of chronic hepatitis C patients with genotype 1b and high viral loads, whose hepatitis C virus was not eradicated by earlier IFN therapy or by pegylated IFN plus ribavirin (PEG-IFN/RBV) combination therapy. In this study, we assessed the early viral dynamics of 9 patients with non-sustained virological response to the combination therapy. The overall viral dynamics of DFPP plus IFN treatment with or without RBV for 4 weeks showed a reduction of ≥1 log in the viral load in 22% (2 of 9 patients), 55.6% (5/9), 77.8% (7/9) and 77.8% (7/9) at 24 h, 1, 2 and 4 weeks after the start of treatment. By contrast, DFPP plus consecutive intravenous IFN-β for 4 weeks reduced the viral load by ≥1 log in 33% (2/6), 50% (3/6), 83.3% (5/6) and 83.3% (5/6) at 24 h, 1, 2 and 4 weeks. The viral load declined by ≥2 log in 50% (3/6) at 4 weeks after the start of treatment. DFPP plus consecutive intravenous IFN-β for 4 weeks is a promising treatment for non-sustained virolgical response patients. Copyright © 2010 S. Karger AG, Basel
- Subjects
HEPATITIS C; PLASMAPHERESIS; VIRAL load; INTERFERONS; INFECTION treatment; ANTIVIRAL agents
- Publication
Intervirology, 2010, Vol 53, Issue 1, p44
- ISSN
0300-5526
- Publication type
Article
- DOI
10.1159/000252783