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- Title
Ultraviolet B radiation to the eye induces pigmentation in the epidermis via the activation of the subunit gp91 phox of reduced nicotinamide adenine dinucleotide phosphate oxidase.
- Authors
Hiramoto, K.; Sato, E. F.
- Abstract
Summary Irradiation by ultraviolet (UV)B is known to increase the number of dopamine (Dopa)-positive melanocytes in the skin. In this study, a 2.5-kJ/m2 dose of UVB radiation was delivered by a sunlamp to the ear or the eye of wild-type C57BL/6j mice and of gp91 phox−/− C57BL/6j mice that had a knockout mutation of the gp91 phox subunit of reduced nicotinamide adenine dinucleotide phosphate oxidase (NADPH). The degree of change in the Dopa-positive melanocyte expression in was reduced in gp91 phox−/− mice given UVB irradiation to the eye, but not in those given irradiation to the ear. The plasma level of α-melanocyte-stimulating hormone (α-MSH) in the blood increased in the C57BL/6j mice after irradiation to either the eye or the ear, but it did not increase in the gp91 phox−/− mice given UVB irradiation to the eye. Both gp91 phox and α-MSH in the central nervous system seem to contribute to pigmentation after UVB irradiation of the eye in mice.
- Subjects
EPIDERMIS; EYE color; NICOTINAMIDE; NAD+ synthase; ULTRAVIOLET radiation; TREATMENT of eye diseases; LABORATORY mice
- Publication
Clinical & Experimental Dermatology, 2012, Vol 37, Issue 1, p65
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/j.1365-2230.2011.04149.x