We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chemoarchitecture of the internal basilar nucleus in the human spinal cord.
- Authors
Şengül, Gülgün; Kırbıyık, Eylem Didem Gülşen; Candar, Esra; Demirçubuk, İbrahim
- Abstract
Objective: The internal basilar nucleus (IB) is located within the confines of lamina 4 of C1-C6 segments in the ventromedial region of the spinal cord's dorsal horn. IB neurons receive afferents from the median and ulnar nerves and project to the thalamus. IB has been demonstrated in cat, rat, hamster, mouse, marmoset monkey, rhesus monkey, and humans. A limited number of studies have shown the immunoreactivity of parvalbumin, calbindin, calmodulin, calretinin, and vesicular glutamate transporter one in rat IB. This study aimed to investigate the neurochemical content of IB in the human spinal cord. Methods: To examine the neurochemical organization of the human IB, 10% formalin-fixed C1-C6 segments of the human spinal cord were sectioned using a cryostat. Subsequently, 30-micrometer thick sections were stained using immunohistochemical markers of calcitonin gene-related peptide, choline acetyltransferase, enkephalin, glycine, glutamate, serotonin, and substance P. Results: Immunoreactivity of calcitonin gene-related peptide, choline acetyltransferase, enkephalin, glycine, glutamate, serotonin, and substance P was observed in human IB neurons under light microscopy. Conclusion: The findings of this study demonstrate the neurochemical organization of IB in the human spinal cord for the first time and suggest its association with pain.
- Subjects
SPINAL cord; CALCITONIN gene-related peptide; SUBSTANCE P; ULNAR nerve; GLUTAMATE transporters
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2024, Vol 18, pS17
- ISSN
1307-8798
- Publication type
Article