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- Title
Keratolytic Molecule Aided Inhibition of DNA Damage and Tyrosinase Activity of a Herbal Formulation.
- Authors
Sripathi, Shubashini K.; Lalitha, P.
- Abstract
The potency of DNA damage inhibition and tyrosinase activity of leaf extract of Pisonia grandis in the form of a skin cream has been established in this research work by in vitro assays. The heterocyclic ureide molecule allantoin is a natural ingredient found in cosmetic products and is proved to be safe and effective in skin protection. The FDA has acknowledged its use in specific concentrations for protecting the skin owing to its non-toxic, non-irritant, nonallergenic, moisturizing, keratolytic, cell proliferating, skin protecting, wound healing, anti-asthmatic, free radical scavenging and several other properties. The skin whitening effect of Pisonia grandis may be attributed to the presence of the keratolytic molecule allantoin in its extracts. Allantoin is compatible with cosmetic raw materials and meets CTFA and JSCI requirements. The formulated skin cream samples showed better potency in terms of DNA damage inhibition and anti-tyrosinase activity in comparison to two commercial skin creams taken for reference. The antioxidant and tyrosinase reducing activity of extracts of Pisonia grandis opens up avenues for their possible use in cosmetic field.
- Subjects
DNA damage; PHENOL oxidase; ALLERGENIC extracts; ALLANTOIN; ANTIOXIDANTS
- Publication
International Journal of BioSciences & Technology, 2016, Vol 9, Issue 2, p7
- ISSN
0974-3987
- Publication type
Article