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- Title
Rolul unor biomarkeri în monitorizarea recidivelor la pacienţii cu cancer de vezică urinară.
- Authors
Glück G., G.; Stoica, R.; Neagoe, L.; Sinescu, I.; Vesa, N.
- Abstract
Purpose A comparative study between new tumor markers (Bladder Tumor Antigen - BTA Trak, Urinary Bladder Cancer Antigen - UBC, Tissue Polypeptide Specific Antigen - TPS), urinary cytology and cystoscopy for detection of the early recurrences during the follow up of the superficial bladder tumors. Patients and methods This study included a group of 69 patients with superficial bladder tumors (pTa and pT1), treated between 2000-2006. Beside the classical follow up of these patients (cytology and cystoscopy), in the last 30 months we included 3 tumor markers (BTA Trak, UBC, TPS). Tumor markers BTA Trak (Bard Diagnostic Sciences, Inc., Redmond, Washington), UBC (IDL Biotech) and TPS (IDL Biotech) were determined by enzyme linked immunoabsorbent assay. Cutoffs were obtained by the 95% percentile and its were 14 U/ml for BTA Trak, 12, ng/ml for UBC and 80 U/l for TPS. Results For BTA Trak: sensitivity 79.16%, specificity 89.47%, positive predictive value 94.44% and negative predictive value 65.51 %; UBC: sensitivity 21.73%, specificity 83.69%, positive predictive value 81.05% and negative predictive value 25%; TPS: sensitivity 57.89%, specificity 46.98%, positive predictive value 82.97% and negative predictive value 20%; Citologie: sensitivity 45,5%, specificity 96.87%, positive predictive value 61.57 % and negative predictive value 50%. Conclusions The sensitivities of tumor markers BTA Trak, UBC and TPS appeared to be high enough so as to substitute urinary cytology. The results of the study indicate that the BTA Trak assay may be a useful adjunct to cystoscopy for detection of the early recurrences during the follow up of the superficial bladder tumors.
- Subjects
BLADDER cancer; TUMOR markers; TUMORS; CYTOLOGY; CYSTOSCOPY; CANCER relapse; COMPARATIVE studies; QUANTITATIVE research; RESEARCH methodology; PATIENTS
- Publication
Romanian Journal of Urology, 2009, Vol 8, Issue 4, p29
- ISSN
1223-0650
- Publication type
Article