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- Title
β-Catenin expression during vascular development and degeneration of avian mesonephros.
- Authors
Nacher, Víctor; Carretero, Ana; Navarro, Marc; Armengol, Clara; Llombart, Cristina; Blasi, Juan; Ruberte, Jesús
- Abstract
β-Catenin is a structural component of adherens junctions, a regulator of the Wnt signalling pathway and a transcriptional co-activator with a key role in vascular patterning. The avian mesonephros is a transitory embryonic kidney that is used in the study of vascular development and degeneration. Here we examineβ-catenin expression in this model during vascular development and degeneration. Quail embryos with developing or degenerating mesonephros were studied, on day 6 (30HH) or day 11 of incubation (40HH), respectively. QH1 whole mounts of developing mesonephros revealed numerous angioblast-like cells situated in the paramesonephric duct that seem to invade the mesonephros. Although these cells did not expressβ-catenin, the surrounding periductal mesenchymal cells translocated high levels ofβ-catenin into the nucleus. In contrast, degenerating mesonephros were devoid of angioblast-like cells andβ-catenin was lower than in the developing mesonephros.β-Catenin was significantly reduced in the glomerular capillary tuffs, indicating that it was particularly down-regulated in the vascular system. No sex-related differences inβ-catenin expression were observed in degenerating mesonephros. Furthermore, two special populations of glomerular and peritubular endothelial cells were observed in degenerating mesonephros: one translocatingβ-catenin into the nucleus and the other in apoptosis that did not translocate it. In conclusion, our results indicate that the paramesonephric duct is a potential new vasculogenetic pathway, and suggest thatβ-catenin plays a role in the fate of mesonephric endothelial cells.
- Subjects
WOLFFIAN body; APOPTOSIS; EUGENICS; DEGENERATION (Pathology); CELLS; ANATOMY
- Publication
Journal of Anatomy, 2005, Vol 206, Issue 2, p165
- ISSN
0021-8782
- Publication type
Article
- DOI
10.1111/j.1469-7580.2005.00382.x