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- Title
The risk factors of early arterial stiffness in type 2 diabetes without diabetic macroangiopathy.
- Authors
Wu, Jia-Hui; Wang, Rui; Jia, Xiao-Jiao; Lu, Na; Lu, Qiang; Yin, Fu-Zai; Ma, Chun-Ming
- Abstract
Background: Type 2 diabetes exposes the body to a state of high blood sugar for a long time and causes varying degrees of hardening of the arteries, making it more prone to cardiovascular emergencies. Objective: The aim of the study was to explore the risk factors of early arterial stiffness in patients with type 2 diabetes mellitus (T2DM). Methods: A retrospective study was conducted on 316 T2DM patients without macroangiopathy in The First Hospital of Qinhuangdao. Early arterial stiffness was evaluated by brachial-ankle pulse wave velocity (baPWV). Results: Ninety patients (28.5%) had baPWV≥1800cm/s. baPWV showed positive correlation with systolic blood pressure (r=0.456, p<0.001), diastolic blood pressure (r=0.133, p=0.018), urine albumin-creatinine ratio (UACR) (r=0.232, p<0.001), neutrophil lymphocyte ratio (NLR) (r=0.185, p=0.001), and visceral fat area (r=0.139, p=0.014). In multiple linear regression analysis, systolic blood pressure (β=6.240, p<0.001), UACR (β=3.805, p=0.019), NLR (β=43.722, p=0.013), and visceral fat area (β=0.778, p=0.030) were significant independent predictors for baPWV. Conclusion: The decline of arterial elasticity was common in T2DM patients without macroangiopathy. Elevated blood pressure, microangiopathy, chronic inflammation, and visceral fat accumulation were the risk factors of early arterial stiffness in patients with T2DM.
- Subjects
CHINA; RISK assessment; STATISTICAL correlation; NEUTROPHIL lymphocyte ratio; ARTERIAL diseases; CREATININE; ADIPOSE tissues; PREDICTION models; MULTIPLE regression analysis; ELASTICITY; CARDIOVASCULAR diseases risk factors; RETROSPECTIVE studies; DESCRIPTIVE statistics; AGE factors in disease; TYPE 2 diabetes; RESEARCH; MEDICAL records; ACQUISITION of data; DIASTOLIC blood pressure; PULSE wave analysis; SYSTOLIC blood pressure; ALBUMINS; INFLAMMATION; DIABETIC angiopathies; BRACHIAL artery
- Publication
International Journal of Diabetes in Developing Countries, 2024, Vol 44, Issue 2, p271
- ISSN
0973-3930
- Publication type
Article
- DOI
10.1007/s13410-023-01220-5