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- Title
Animal Models of Chikungunya Virus Infection and Disease.
- Authors
Haese, Nicole N.; Broeckel, Rebecca M.; Hawman, David W.; Heise, Mark T.; Morrison, Thomas E.; Streblow, Daniel N.
- Abstract
Chikungunya virus (CHIKV) is a reemerging alphavirus that causes acute febrile illness and severe joint pain in humans. Although acute symptoms often resolve within a few days, chronic joint and muscle pain can be long lasting. In the last decade, CHIKV has caused widespread outbreaks of unprecedented scale in the Americas, Asia, and the Indian Ocean island regions. Despite these outbreaks and the continued expansion of CHIKV into new areas, mechanisms of chikungunya pathogenesis and disease are not well understood. Experimental animal models are indispensable to the field of CHIKV research. The most commonly used experimental animal models of CHIKV infection are mice and nonhuman primates; each model has its advantages for studying different aspects of CHIKV disease. This review will provide an overview of animal models used to study CHIKV infection and disease and major advances in our understanding of chikungunya obtained from studies performed in these models.
- Subjects
CHIKUNGUNYA virus; INFECTION; MEDICAL microbiology; ALPHAVIRUSES; ANIMAL models in research; ANIMALS; BIOLOGICAL models; MICE; PRIMATES; CHIKUNGUNYA; PHYSIOLOGY
- Publication
Journal of Infectious Diseases, 2016, Vol 214, pS482
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiw284