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- Title
Transmission Clustering Drives the Onward Spread of the HIV Epidemic Among Men Who Have Sex With Men in Quebec.
- Authors
Brenner, Bluma G.; Roger, Michel; Stephens, David; Moisi, Daniela; Hardy, Isabelle; Weinberg, Jonathan; Turgel, Reuven; Charest, Hugues; Koopman, James; Wainberg, Mark A.
- Abstract
Phylodynamic analysis and epidemiologic data identified 3 patterns of spread of primary human immunodeficiency virus type 1 infection (PHI) among men who have sex with men (2001-2009): 420 unique PHIs, 102 small clusters (2-4 PHIs per cluster, n = 280), and 46 large clusters (5-31 PHIs per cluster, n 5 450). Large clusters disproportionately increased from 25.2%of PHIs in 2005 to 39.1%in 2009 (x2 = 33.9, P < .001). Scalar expansion of large clusters over 11 months (interquartile range, 3.5-25.5 months) correlated with cluster membership size (r2 = 0.174, F = 4.424, P = .047). PHI cohort data revealed variations in social networks and risk behaviors among the 3 groups, suggesting the need for tailored prevention measures.
- Subjects
QUEBEC (Quebec); HIV infections; MEN who have sex with men; COMMUNICABLE diseases; EPIDEMIOLOGY; SOCIAL networks; EPIDEMICS
- Publication
Journal of Infectious Diseases, 2011, Vol 204, Issue 7, p1115
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jir468