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- Title
Cell sex determines anoikis resistance in vascular smooth muscle cells
- Authors
Straface, Elisabetta; Vona, Rosa; Gambardella, Lucrezia; Ascione, Barbara; Marino, Maria; Bulzomi, Paola; Canu, Silvia; Coinu, Rita; Rosano, Giuseppe; Malorni, Walter; Franconi, Flavia
- Abstract
Abstract: Sexual dimorphism, detectable in vascular smooth muscle cells freshly isolated from aorta of male and female rats, is associated with a different susceptibility to radiation-induced apoptosis. In this work we investigated the mechanism underlying this difference and discovered that, in comparison with cells from male rats, cells from female rats show adhesion-associated resistance to apoptosis, the so called anoikis resistance. This is apparently due to a more adhering phenotype, characterized by a well organized actin microfilament cytoskeleton and to an increased phosphorylated focal adhesion kinase, and, more importantly, to a higher propensity to undergo survival by autophagy.
- Subjects
MUSCLE cells; REACTIVE oxygen species; CELL adhesion; APOPTOSIS; ESTRADIOL; ELECTRON microscope techniques; FOCAL adhesion kinase; CELLULAR aging
- Publication
FEBS Letters, 2009, Vol 583, Issue 21, p3448
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2009.09.052