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- Title
Changes in subcellular localization of fructose 1,6-bisphosphatase during differentiation of isolated muscle satellite cells
- Authors
Gizak, A.; Wrobel, E.; Moraczewski, J.; Dzugaj, A.
- Abstract
Abstract: Subcellular localization of FBPase, a regulatory enzyme of glyconeogenesis, was examined inside dividing and differentiating satellite cells from rat muscle. In dividing myoblasts, FBPase was located in cytosol and nuclei. When divisions ceased, FBPase became restricted to the cytosolic compartment and finally was found to associate with the Z-lines, as in adult muscle. Moreover, a 12-fold decrease was observed in the number of FBPase-positive nuclei associated with muscle fibres of adult rat, as compared with young muscle, possibly reflecting the reduction in number of active satellite cells during muscle maturation. The data might suggest that FBPase participates in some nuclear processes during development and regeneration of skeletal muscle.
- Subjects
ENZYMES; MUSCLE cells; CELL nuclei; CYTOPLASM
- Publication
FEBS Letters, 2006, Vol 580, Issue 17, p4042
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2006.06.042