We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Molecular recognition of nucleic acids: Coralyne binds strongly to poly(A)
- Authors
Xing, Feifei; Song, Guangtao; Ren, Jinsong; Chaires, Jonathan B.; Qu, Xiaogang
- Abstract
Abstract: The small molecule coralyne was found to bind preferentially and strongly to single-stranded poly(A) with an apparent association constant (K a) of (1.8±0.3)×106 M−1. Binding of coralyne to poly(A) is predominantly enthalpically driven with a stoichiometry of one coralyne per four adenine bases. Poly(A) forms a coralyne dependent secondary structure with a melting temperature of 60°C, for the conditions of our study.
- Subjects
NUCLEIC acids; MOLECULAR biology; RNA; STOICHIOMETRY
- Publication
FEBS Letters, 2005, Vol 579, Issue 22, p5035
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.07.091