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- Title
Impact of a predefined mediastinal ROI on inter-observer variability of planar I-MIBG heart-to-mediastinum ratio.
- Authors
Verschure, Derk; Bongers, Vivian; Hagen, Petronella; Somsen, G.; Eck-Smit, Berthe; Verberne, Hein
- Abstract
Aim: Purpose of this study was to assess the impact of mediastinal region of interest (ROI) definition on intra- and inter-observer variability in relation to collimator type. Methods: Thirty-five subjects with CHF (80% men, mean age 66 ± 9 years, NYHA 2.4 ± 0.5, LVEF 29 ± 8.4%) were enrolled. 15 minutes and 4 hours post-injection (p.i.) of I-MIBG, planar images were sequentially acquired with low energy high energy (LEHR) and medium energy (ME) collimators. In the first analysis, observer-defined mediastinal ROI was used. In the second analysis, a predefined mediastinal ROI was used. Intra- and inter-observer variability of late H/ M was assessed using Lin's concordance coefficient (LCC). Results: There was substantial agreement between all three observers using predefined mediastinum ROI. LCCs for LEHR were 0.98, 0.96, and 0.95, for ME 0.98, 0.97, and 0.97. However, observer-defined mediastinal ROI resulted in poor-moderate agreement. LCCs for LEHR were 0.82, 0.94, and 0.70, for ME 0.77, 0.91, and 0.80. Intra-observer analysis using predefined mediastinal ROI showed substantial agreement. LCC was 0.97 for LEHR and 0.96 for ME. Conclusion: Predefined mediastinal ROI results in low intra- and inter-observer variability of late H/ M and is, therefore, to be preferred over observer-defined mediastinal ROI. Intra- and inter-observer variability of late H/ M is not influenced by collimator choice.
- Subjects
MEDIASTINUM; POSITRON emission tomography; COEFFICIENTS (Statistics); HEART failure; NUCLEAR medicine; CARDIOLOGY; COLLIMATORS
- Publication
Journal of Nuclear Cardiology, 2014, Vol 21, Issue 3, p605
- ISSN
1071-3581
- Publication type
Article
- DOI
10.1007/s12350-014-9854-z