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- Title
Temperature- and pH-Dependent Drug Release of Block Copolymers of Methacrylic Acid and Poly(Ethylene Glycol) Methyl Ether Methacrylates.
- Authors
Atayde Jr., Eduardo C.; Montalbo, Reynaldo Carlos K.; Arco, Susan D.
- Abstract
The block copolymers, poly(methacrylic acid)-b-poly(di(ethylene glycol) methyl ether methacrylate) (Block-D) and poly(methacrylic acid)-b-poly(poly(ethylene glycol) methyl ether methacrylate) (Block-P) were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization towards the development of stimuli-responsive carriers of poorly water-soluble drugs. The structures of the copolymers and the confirmation of successful block copolymerization were studied using proton nuclear magnetic resonance (1H-NMR) spectroscopy. Data from gel permeation chromatography (GPC) then showed polydispersity indices (PDI) close to 1.0, characteristic of RAFT polymerization. Stimuli-response studies revealed Block-D was responsive at pH 5.15 and 26°C while Block-P was responsive at pH 5.15 and 72°C. The corresponding micelles had particle sizes of 92.95-201.4 nm, as determined by dynamic light scattering (DLS), with critical micelle concentration (CMC) at about 10-1 mg/mL, per fluorescence studies. Using ibuprofen as the model drug, the drug loading content reached 11.76%, at 66.65% efficiency. In vitro release profiles then demonstrated 18% drug release within 5 h at stomach-like conditions, and 65% release within 5 h at small intestine-like conditions. Ultimately, cell viability assays of the blank and loaded micelles confirmed that neither is cytotoxic. These results show the immense potential and capability of the synthesized material as a drug delivery system for poorly water-insoluble drugs.
- Subjects
PH effect; BLOCK copolymers; POLYMETHACRYLIC acids; POLYETHYLENE glycol; METHYL ether
- Publication
Philippine Journal of Science, 2018, Vol 147, Issue 3, p363
- ISSN
0031-7683
- Publication type
Article