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- Title
A twin study of weight loss and metabolic efficiency.
- Authors
Hainer, V; Stunkard, A; Kunešová, M; Parízková, J; Štich, V; Allison, D B
- Abstract
OBJECTIVE: To assess the genetic contribution to determinants of therapeutic weight loss in obese female identical twins. DESIGN: Subjects were studied for 40 days on an inpatient unit in three phases: 7 baseline days; 28 days of weight reduction by a very low calorie diet (1.6 MJ per day); and 5 days after weight reduction. SUBJECTS: Fourteen pairs of premenopausal obese female identical twins (age: 39.0 ± 1.7 y; body weight (BW): 93.9 ± 21.2 kg; body mass index (BMI): 34.2 ± 7.8 kg/m²). MEASUREMENTS: Body composition by hydrodensitometry and resting metabolic rate by indirect calorimetry were assessed before and after weight loss. RESULTS: There was great variability among pairs in loss of weight (5.9-12.4 kg) and body fat (3.1-12.4 kg). By contrast, the intraclass correlation (ICC) within twin pairs was 0.85, P < 0.001 for weight and 0.88, P < 0.001 for body fat. A measure of metabolic efficiency, calculated as the difference between 'estimated' and 'measured' energy deficit showed high intrapair correlation (ICC = 0.77; P < 0.001). CONCLUSIONS: The high correlation in metabolic efficiency within twin pairs in response to therapeutic weight loss suggests a strong genetic contribution.
- Subjects
WEIGHT loss; METABOLISM; OBESITY; TWINS
- Publication
International Journal of Obesity & Related Metabolic Disorders, 2001, Vol 25, Issue 4, p533
- ISSN
0307-0565
- Publication type
Article
- DOI
10.1038/sj.ijo.0801559