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- Title
High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer.
- Authors
Gaber, A.; Johansson, M.; Stenman, U.-H.; Hotakainen, K.; Pontén, F.; Glimelius, B.; Bjartell, A.; Jirström, K.; Birgisson, H.; Pontén, F; Jirström, K
- Abstract
Increased expression of tumour-associated trypsin inhibitor (TATI) in tumour tissue and/or serum has been associated with poor survival in various cancer forms. Moreover, a proinvasive function of TATI has been shown in colon cancer cell lines. In this study, we have examined the prognostic significance of tumour-specific TATI expression in colorectal cancer, assessed by immunohistochemistry (IHC) on tissue microarrays (TMAs) with tumour specimens from two independent patient cohorts. Kaplan-Meier analysis and Cox proportional hazards modelling were used to estimate time to recurrence, disease-free survival and overall survival. In both cohorts, a high (>50% of tumour cells) TATI expression was an independent predictor of a significantly shorter overall survival. In cohort II, in multivariate analysis including age, gender, disease stage, differentiation grade, vascular invasion and carcinoembryonal antigen (CEA), high TATI expression was associated with a significantly decreased overall survival (HR=1.82; 95% CI=1.19-2.79) and disease-free survival (HR=1.56; 95% CI=1.05-2.32) in curatively treated patients. Moreover, there was an increased risk for liver metastasis in both cohorts that remained significant in multivariate analysis in cohort II (HR=2.85; 95% CI=1.43-5.66). In conclusion, high TATI expression is associated with liver metastasis and is an independent predictor of poor prognosis in patients with colorectal cancer.
- Subjects
TRYPSIN inhibitors; ENZYME inhibitors; LIVER metastasis; COLON cancer; CANCER cells; CANCER invasiveness; CANCER diagnosis; CANCER-related mortality; TISSUE arrays; BIOCHEMISTRY; RESEARCH; LIVER tumors; ACUTE phase proteins; RESEARCH methodology; PROGNOSIS; MEDICAL cooperation; EVALUATION research; COLORECTAL cancer; CANCER; DISEASE relapse; PHENOMENOLOGY; COMPARATIVE studies; SURVIVAL analysis (Biometry); LONGITUDINAL method
- Publication
British Journal of Cancer, 2009, Vol 100, Issue 10, p1540
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/sj.bjc.6605047