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- Title
A case of naturally occurring anti-Di<sup>a</sup> antibody in a young man.
- Authors
Iberahim, Salfarina; Noor, Noor; Hassan, Mohd; Bahar, Rosnah; Yusoff, Shafini; Ramli, Marini; Abdul Rahman, Wan; Zulkafli, Zefarina; Abdullah, Marne; Fong, Ho; Mohamed Shihabudin, Tengku; Edinur, Hisham; Che Ghazali, Norul
- Abstract
The Diego (Di) blood group system comprises 22 antigens located on the band 3 protein, most of which are low-prevalence antigens. The majority of antibodies to Diego system antigens were of clinically insignificant; however anti-Dia, -Dib, -Wra, -ELO and-DISK may cause hemolytic disease of the fetus and newborn (HDFN) and transfusion reaction. We reported a case of naturally occurring of anti-Dia in a young man who presented to our hospital for wound debridement of fingers injury. His serological results were suggestive of anti-Dia antibody, and his molecular blood group showed he has Di (a-b+) antigen. Anti-Dia may be clinically significant. It can cause mild-to-severe HDFN, but there are only infrequent reports of it being clearly implicated in a hemolytic transfusion reaction. We suggest the need for reagent red blood cell panels to include Dia antigen-positive cells in antibody identification tests for our populations.
- Subjects
IMMUNOGLOBULINS; BLOOD proteins; FINGER injuries; SERODIAGNOSIS; BLOOD groups; BLOOD diseases; RED blood cell transfusion; ANTIGENS
- Publication
Asian Journal of Transfusion Science, 2022, Vol 16, Issue 2, p276
- ISSN
0973-6247
- Publication type
Article
- DOI
10.4103/ajts.ajts_136_21