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- Title
Therapy-induced drug resistance in a human leukemia line (LALW-2). A clinically relevant model.
- Authors
White, Les; Haber, Michelle; Brian, Michael J.; Norris, Murray D.; Trickett, Annette; Sosula, Leo; Tiley, Campbell; Stewart, Bernard W.; White, L; Haber, M; Brian, M J; Norris, M D; Trickett, A; Sosula, L; Tiley, C; Stewart, B W
- Abstract
A human leukemic T-cell line, LALW-2, established by xenografting in nude mice, has been maintained through 14 serial passages. The cells display consistent morphologic features, immunophenotype, and karyotypic aberrations (including an 11;14 translocation) and exhibit rearrangement of the T-cell receptor beta-chain gene. The growth rate of LALW-2 xenografts was differentially affected by drugs administered to host mice, the cells being resistant to cytotoxic agents (particularly methotrexate and doxorubicin) used in treatment of the donor patient. In short-term in vitro culture, LALW-2 cells exhibited extreme resistance to methotrexate and were also resistant to vincristine, vinblastine, dactinomycin, and doxorubicin. The findings differ from those obtained with laboratory-derived methotrexate or multidrug-resistant cell lines. The response of LALW-2 cells, in both the nude mouse model and in vitro, is consistent with acquisition of drug-resistance as a result of clinical treatment.
- Publication
Cancer (0008543X), 1989, Vol 63, Issue 11, p2103
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19890601)63:11<2103::AID-CNCR2820631106>3.0.CO;2-N