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- Title
Association of the FTO Obesity Risk Variant rs8050136 With Percentage of Energy Intake From Fat in Multiple Racial/Ethnic Populations.
- Authors
Park, Sungshim Lani; Cheng, Iona; Pendergrass, Sarah A.; Kucharska-Newton, Anna M.; Lim, Unhee; Ambite, Jose Luis; Caberto, Christian P.; Monroe, Kristine R.; Schumacher, Fredrick; Hindorff, Lucia A.; Oetjens, Matthew T.; Wilson, Sarah; Goodloe, Robert J.; Love, Shelly-Ann; Henderson, Brian E.; Kolonel, Laurence N.; Haiman, Christopher A.; Crawford, Dana C.; North, Kari E.; Heiss, Gerardo
- Abstract
Common obesity risk variants have been associated with macronutrient intake; however, these associations' generalizability across populations has not been demonstrated. We investigated the associations between 6 obesity risk variants in (or near) the NEGR1, TMEM18, BDNF, FTO, MC4R, and KCTD15 genes and macronutrient intake (carbohydrate, protein, ethanol, and fat) in 3 Population Architecture using Genomics and Epidemiology (PAGE) studies: the Multiethnic Cohort Study (1993–2006) (n = 19,529), the Atherosclerosis Risk in Communities Study (1987–1989) (n = 11,114), and the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) Study, which accesses data from the Third National Health and Nutrition Examination Survey (1991–1994) (n = 6,347). We used linear regression, with adjustment for age, sex, and ethnicity, to estimate the associations between obesity risk genotypes and macronutrient intake. A fixed-effects meta-analysis model showed that the FTO rs8050136 A allele (n = 36,973) was positively associated with percentage of calories derived from fat (βmeta = 0.2244 (standard error, 0.0548); P = 4 × 10−5) and inversely associated with percentage of calories derived from carbohydrate (βmeta = −0.2796 (standard error, 0.0709); P = 8 × 10−5). In the Multiethnic Cohort Study, percentage of calories from fat assessed at baseline was a partial mediator of the rs8050136 effect on body mass index (weight (kg)/height (m)2) obtained at 10 years of follow-up (mediation of effect = 0.0823 kg/m2, 95% confidence interval: 0.0559, 0.1128). Our data provide additional evidence that the association of FTO with obesity is partially mediated by dietary intake.
- Subjects
UNITED States; OBESITY genetics; RESEARCH; ALLELES; CARBOHYDRATES; CONFIDENCE intervals; CONSORTIA; STATISTICAL correlation; FAT content of food; GENES; INGESTION; MEDICAL cooperation; META-analysis; NUTRITIONAL requirements; QUESTIONNAIRES; REGRESSION analysis; RESEARCH funding; STATISTICS; EVIDENCE-based medicine; PROFESSIONAL practice; DATA analysis; BODY mass index; STATISTICAL models; DESCRIPTIVE statistics
- Publication
American Journal of Epidemiology, 2013, Vol 178, Issue 5, p780
- ISSN
0002-9262
- Publication type
Article
- DOI
10.1093/aje/kwt028