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- Title
Micro RNAs and lymphomagenesis: a functional review.
- Authors
Lawrie, Charles H.
- Abstract
The relatively recent discovery of micro RNAs (mi RNAs) has exposed an extra layer of gene expression regulation that affects many physiological and pathological processes of biology. Dysregulation of mi RNAs is a ubiquitous feature of cancer in general, including lymphomas. The identity of these aberrantly-expressed mi RNAs has been thoroughly investigated in all but a few types of lymphomas, however their functional role in lymphomagenesis much less so. This review focuses on those mi RNAs that have an experimentally confirmed functional role in the pathogenesis of the most frequent forms of lymphoma. In particular, the MIR15A/16-1 cluster, MIR21, MIR155, MIR17 HG ( MIR17-92 cluster) , MIR34A and MIR125B, which have in vivo animal model evidence for their involvement in lymphomagenesis, are highlighted.
- Subjects
MICRORNA genetics; GENE expression; LYMPHOMAS; LYMPHATIC cancer -- Etiology; CARCINOGENESIS; LIFE sciences
- Publication
British Journal of Haematology, 2013, Vol 160, Issue 5, p571
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.12157