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- Title
Suppressor alphabeta T lymphocytes control innate resistance to endotoxic shock.
- Authors
Jones-Carson J; Fantuzzi G; Siegmund B; Dinarello C; Tracey KJ; Wang H; Fang FC; Vazquez-Torres A; Jones-Carson, Jessica; Fantuzzi, Giamila; Siegmund, Britta; Dinarello, Charles; Tracey, Kevin J; Wang, Haichao; Fang, Ferric C; Vazquez-Torres, Andres
- Abstract
A considerable amount of research has focused on elucidating the mechanisms by which cytokines synthesized by cells of the innate immune system participate in the life-threatening multiple-organ failure of endotoxic shock. We show here that alphabeta T cells, which are archetypes of the adaptive cellular immune response, suppress the proinflammatory cascade triggered during the early stages of lipopolysaccharide (LPS)-induced endotoxemia. The absence of alphabeta T cells led to the fulminant death of LPS-challenged mice, coinciding with a massive release of the proinflammatory cytokines tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma and a marked reduction in the synthesis of the immunosuppressive cytokine transforming growth factor (TGF)-beta. Cytotoxic T lymphocyte antigen (CTLA)-positive alphabeta T cells emerging shortly after LPS challenge appear to control TGF-beta synthesis. The neutralization of either TGF-beta or CTLA4 resulted in similar increases in IFN-gamma and TNF-alpha serum concentrations in LPS-challenged mice. These observations suggest that suppressor alphabeta T lymphocytes protect against the proinflammatory cascade unleashed during the innate stages of endotoxemia.
- Publication
Journal of Infectious Diseases, 2005, Vol 192, Issue 6, p1039
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1086/432727