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- Title
Human Leukocyte Antigen Class II Alleles and Rubella-Specific Humoral and Cell-Mediated Immunity following Measles-Mumps-Rubella-II Vaccination.
- Authors
Ovsyannikova, Inna G.; Jacobson, Robert M.; Vierkant, Robert A.; Jacobsen, Steven J.; Pankratz, V. Shane; Poland, Gregory A.
- Abstract
We examined associations between human leukocyte antigen (HLA) class II genes and both rubella-specific immunoglobulin G antibodies and lymphoproliferative responses after measles-mumps-rubella-II (MMR-II) vaccination, in a population- based sample of 346 school children. The DPB1*0301, DPB1*0401, DPB1*1301, and DPB1*1501 alleles were significantly associated with rubella vaccine-induced antibodies. Alleles suggestive of being positively associated with rubella- specific lymphoproliferative stimulation indices were DPB1*0301, DQB1*0501, DRB1*0101, and DRB1*1104. Conversely, the DPB1*0401, DPB1*1001, DPB1*1101, DQB1*0202, and DRB1*0701 alleles were negatively associated with rubella- specific lymphoproliferation. This study of HLA class II-restricted humoral and cellular immune responses to rubella provides significant insight into mechanisms of vaccine response and new vaccine development.
- Subjects
LEUCOCYTES; HLA histocompatibility antigens; IMMUNOGLOBULINS; VIRAL vaccines; IMMUNE response; PREVENTIVE medicine
- Publication
Journal of Infectious Diseases, 2005, Vol 191, Issue 4, p515
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/427558