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- Title
Vitamin A Supplementation and Genital Shedding of Herpes Simplex Virus among HIV-1--Infected Women: A Randomized Clinical Trial.
- Authors
Baeten, Jared M.; McClelland, R. Scott; Corey, Lawrence; Overbaugh, Julie; Lavreys, Ludo; Richardson, Barbra A.; Wald, Anna; Mandaliya, Kishorchandra; Bwayo, Job J.; Kreiss, Joan K.
- Abstract
Cross-sectional analyses have associated vitamin A deficiency with genital shedding of herpes simplex virus (HSV) among human immunodeficiency virus type 1 (HIV-1)infected women. A randomized clinical trial of vitamin A supplementation given daily for 6 weeks was conducted among 376 women in Mombasa, Kenya, who were coinfected with HSV-2 and HIV-1. At follow-up, there was no significant difference in the detection of genital HSV DNA between women receiving vitamin A supplementation and women receiving placebo (40% vs. 44%, respectively;P=.5) Among women shedding HSV, there was no significant difference in the mean HSV DNA quantity between the group that received vitamin A supplementation and the group that received placebo (4.51 vs. 4.67 log10 copies/swab;P=.6). HSV shedding was associated with significantly higher vaginal and cervical HIV-1 shedding, even after controlling for the plasma HIV-1 load and the CD4 count. Vitamin A supplementation is unlikely to decrease HSV shedding and infectivity.
- Subjects
CLINICAL trials; VITAMIN A in human nutrition; HERPES simplex virus; HIV-positive women; VITAMIN A deficiency; PLACEBOS; EPIDEMIOLOGY
- Publication
Journal of Infectious Diseases, 2004, Vol 189, Issue 8, p1466
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/383049