We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association between Surfactant Protein A Gene Locus and Severe Respiratory Syncytial Virus Infection in Infants.
- Authors
Löfgren, Johan; Rämet, Mika; Renko, Marjo; Marttila, Riitta; Hallman, Mikko
- Abstract
Respiratory syncytial virus (RSV) causes seasonal epidemics of bronchiolitis among susceptible infants. Surfactant protein A(SP-A), a lung C-type lectin involved in innate host defense, opsonizes RSV and enhances phagocytosis. The candidate gene approach was used to investigate association of SP-A polymorphism with susceptibility to severe RSV infection. Genotype analysis was done for 86 infants with severe RSV infection and 95 matched control subjects. A significant difference in the frequency of SP-A2was observed. The SP-A2 allele 1A 3 was overrepresented inRSV-infectedin-fants, compared with control subjects (5%vs. 0.5%; P .006), whereas allele 1A was underrepresented (1%vs. 6%; P .011). The allele pool in which lysine was amino acid 223 was overrepresented in infants with severe RSV infection (28%vs. 18%; P .023), whereas the allele pool in which proline was amino acid 99 was underrepresented (5%vs. 16%;P .001). These results indicate that a genetic association exists between SP-A gene locus and severe RSV infection.
- Subjects
SURFACE active agents; RESPIRATORY syncytial virus; INFANT diseases
- Publication
Journal of Infectious Diseases, 2002, Vol 185, Issue 3, p283
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/338473