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- Title
Liver Metastasis from Colorectal Cancer in the Elderly: Is Surgery Justified?
- Authors
Xie, Minghao; Zhu, Jinling; He, Xiaosheng; Yang, Zihuan; Chen, Xinlin; Lan, Ping; Lian, Lei
- Abstract
<bold>Background: </bold>The elderly population with liver metastasis from colorectal cancer has been increasing. As the potentially curative treatment, the role of liver resection in the elderly remains undetermined.<bold>Aims: </bold>This study provides a meta-analysis on the outcome of liver resection of colorectal liver metastasis in patients aged over 70.<bold>Methods: </bold>PubMed, Embase, Ovid, Web of Science, and Cochrane databases from the years 2000 to 2015 were searched for eligible studies. Data on perioperative mortality, postoperative complications, and survival were collected.<bold>Results: </bold>Twelve retrospective studies with a total of 11,285 patients (2498 elderly patients and 8787 younger patients) were identified. The elderly (>70 years old) were associated with a similar overall complication rate (30.5 vs. 28.0%; OR 1.08; 95% CI 0.91-1.28; p = 0.39) and a higher 30-day mortality (OR 1.92; 95% CI 1.12-3.31; p = 0.02) after liver resection of colorectal liver metastasis (CRLM). The overall survival showed a significant difference in favor of the younger patients (HR 0.76; 95% CI 0.65-0.89; p = 0.0007). However, with regard to disease-free survival, there was no significant difference between elderly and younger patients (HR 0.93; 95% CI 0.82-1.06; p = 0.30).<bold>Conclusion: </bold>Liver resection of CRLM is relatively safe in carefully selected elderly patients. Liver resection should be offered to selected elderly patients with CRLM.
- Subjects
LIVER cancer; COLON cancer; METASTASIS; OLDER patients; LIVER surgery; META-analysis; RETROSPECTIVE studies; AGE distribution; COLON tumors; COMPARATIVE studies; LIVER tumors; RESEARCH methodology; MEDICAL cooperation; PROGNOSIS; RECTUM tumors; RESEARCH; EVALUATION research
- Publication
Digestive Diseases & Sciences, 2015, Vol 60, Issue 12, p3525
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-015-3789-3