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- Title
Ischemia/Reperfusion in Clamped Lobes Facilitates Liver Regeneration of Non-clamped Lobes After Selective Portal Vein Ligation.
- Authors
Yu, Jian-hua; Zhang, Wei-guang; Jiang, Gui-xing; Zhao, Jia-yun; Li, Hui; Wang, Zhi-dong; Cui, Yun-fu
- Abstract
Background: Hypertrophy of non-clamped liver lobes and the atrophy of clamped lobes have been shown to be interactive. Here, a rat model of selective lobe occlusion was established to study the effect of contralateral ischemia/reperfusion (I/R) on regeneration of non-clamped lobes. Methods: Left lateral and middle liver lobes were pretreated with I/R. In the experimental (IR + PVL) group, portal veins of the left and middle lobes were ligated. A group given similar portal vein ligation but no I/R (PVL) was the positive control. Results: Compared with the PVL group, the IR + PVL had higher, but not remarkable, levels of serum transaminases; weights of non-clamped lobes in the IR + PVL group comparatively increased much more notably. At 24-h post-surgery, the IR + PVL group's PCNA mRNA was up-regulated compared with the PVL group. At 72-h post-surgery, PCNA protein was up-regulated significantly, while TGF-β1 was down-regulated in the IR + PVL group notably, compared with the PVL group. Conclusion: The I/R pretreatment given to the clamped lobes facilitates liver regeneration of non-clamped lobes after selective portal vein ligation, which may result from down-regulated TGF-β1 expression in non-clamped lobes.
- Subjects
LIVER regeneration; REPERFUSION; ISCHEMIA; LIGATURE (Surgery); PORTAL vein surgery; HYPERTROPHY; AMINOTRANSFERASES
- Publication
Digestive Diseases & Sciences, 2012, Vol 57, Issue 12, p3178
- ISSN
0163-2116
- Publication type
Article
- DOI
10.1007/s10620-012-2298-x