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- Title
Very late-phase vascular response after everolimus-eluting stent implantation assessed by optical coherence tomography.
- Authors
Khalifa, Amir Kh. M.; Ino, Yasushi; Kubo, Takashi; Tanimoto, Takashi; Shimamura, Kunihiro; Shiono, Yasutsugu; Takahata, Masahiro; Terada, Kosei; Higashioka, Daisuke; Wada, Teruaki; Taruya, Akira; Emori, Hiroki; Katayama, Yosuke; Kashiwagi, Manabu; Kuroi, Akio; Matsuo, Yoshiki; Fujita, Suwako; Tanaka, Atsushi; Hozumi, Takeshi; Akasaka, Takashi
- Abstract
Long-term safety of second generation drug-eluting stents (DES) has not yet been evaluated. We sought to evaluate the very late phase (> 3 years) vascular response after second generation everolimus-eluting stent (EES) as compared with first generation sirolimus-eluting stent (SES) by using optical coherence tomography (OCT). We examined the vascular response in 39 patients with a total of 55 DESs [31 EESs (mean 54 months after stenting) and 24 first generation SES (mean 66 months after stenting)] by OCT. The frequency of lesions with any malapposed stent struts (19% vs. 46%, p = 0.035) and evagination (6% vs. 42%, p = 0.002) was significantly lower. Segments with malapposed stent struts were significantly shorter (0.4 ± 0.9 mm vs. 1.9 ± 3.5 mm, p = 0.024), maximal malapposition area and malapposition volume were significantly smaller (0.26 ± 0.38 mm2 vs. 0.95 ± 1.54 mm2, p = 0.019, and 0.78 ± 1.35 mm3 vs. 6.22 ± 15.76 mm3, p = 0.016, respectively) in EES. Compared with first generation SES, second generation EES showed more favourable vascular responses at the very late phase.
- Subjects
INTRAVASCULAR ultrasonography; OPTICAL coherence tomography; GENERATIONS
- Publication
International Journal of Cardiovascular Imaging, 2020, Vol 36, Issue 9, p1627
- ISSN
1569-5794
- Publication type
Article
- DOI
10.1007/s10554-020-01877-7