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- Title
Incremental prognostic value of diastolic dysfunction in low risk patients undergoing echocardiography: beyond Framingham score.
- Authors
AlJaroudi, Wael; Alraies, M.; Halley, Carmel; Menon, Venu; Rodriguez, L.; Grimm, Richard; Thomas, James; Jaber, Wael
- Abstract
We sought to assess the prognostic value of diastolic dysfunction (DD) in low-risk adults beyond Framingham risk score (FRS). Consecutive patients without cardiovascular risk factors or co-morbidities were identified from a retrospective cohort. Multivariate binary logistic regression was performed to identify factors associated with DD, and Cox proportional hazard model to evaluate the association of DD with all-cause death. Analysis was repeated by stratifying by the year of the echocardiogram to account for possible time-related shift in measurement techniques. Net reclassification improvement (NRI) was performed to assess incremental prognostic value of DD. The study cohort consisted on 1,039 patients with a mean age (SD) 47.9 (15.7) years. Overall, 346 patients (33.3 %) had DD, among whom 327 were grade 1. Age was the only independent predictor of DD with odds ratio 3.2 (2.8; 3.7) for every 10 years increase ( p < 0.0001). After a mean follow-up time (SD) of 7.3 (1.7) years, 71 (6.8 %) patients died. Adjusting for age, gender, and race, DD remained an independent predictor of all-cause mortality with hazard ratio (95 % CI) 2.03 ( p = 0.029), and similarly after adjusting for FRS (HR 2.73, p = 0.002) which resulted in IDI gain of 1.4 % ( p = 0.0037) and NRI of 15 % ( p = 0.029). In 463 age and gender matched subgroups, DD was still an independent predictor of mortality (HR 2.6 [1.25; 5.55], p = 0.01). In low-risk adult outpatients undergoing echocardiography, DD was associated with 2-3 fold increase in risk of death and had incremental prognostic value beyond FRS.
- Subjects
CARDIOVASCULAR diseases risk factors; THREE-dimensional echocardiography; MULTIVARIATE analysis; LOGISTIC regression analysis; PROPORTIONAL hazards models; ECHOCARDIOGRAPHY
- Publication
International Journal of Cardiovascular Imaging, 2013, Vol 29, Issue 7, p1441
- ISSN
1569-5794
- Publication type
Article
- DOI
10.1007/s10554-013-0246-2