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- Title
Extracellular redox modulation by regulatory T cells.
- Authors
Zhonghua Yan; Garg, Sanjay K.; Kipnis, Jonathan; Banerjee, Ruma
- Abstract
We demonstrate that the mechanism of redox remodeling during mouse T-cell activation involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine. Extracellular cysteine accumulation results in a lower redox potential, which is conducive to proliferation, and changes the net redox status of exofacial protein domains. Regulatory T cells inhibit this redox metabolite signaling pathway, which represents a previously unrecognized mechanism for immunosuppression of effector T cells.
- Subjects
EXTRACELLULAR enzymes; CELL proliferation; OXIDATION-reduction reaction; T cell receptors; DENDRITIC cells
- Publication
Nature Chemical Biology, 2009, Vol 5, Issue 10, p721
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio.212