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- Title
The rule of four.
- Authors
Armitage, Bruce A.
- Abstract
The article presents a research on the biology of the newly discovered G-quadruplex repressor element and the bioinformatics. It is stated that guanine-rich quadruplex-forming sequences within DNA and RNA are prevalent and are suspected of regulating telomere replication, transcription and pre-mRNA splicing. The discovery of quadruplex-forming sequences in the 5' untranslated regions of various proto-oncogenes indicates an important role for such sequences in inhibition of mRNA translation.
- Subjects
PROTO-oncogenes; DNA; BIOINFORMATICS; RESEARCH; RNA splicing; MESSENGER RNA
- Publication
Nature Chemical Biology, 2007, Vol 3, Issue 4, p203
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio0407-203