We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation.
- Authors
Margolin, Yelena; Cloutier, Jean-Francois; Shafirovich, Vladimir; Geacintov, Nicholas E; Dedon, Peter C
- Abstract
Guanine in DNA is a major oxidation target owing to its low ionization potential (IP), and there is often an inverse correlation between damage frequency and sequence-dependent variation in guanine IP. We report that the biological oxidant nitrosoperoxycarbonate (ONOOCO2–) paradoxically selects guanines with the highest IP in GC-containing contexts. Along with sequence-dependent variation in damage chemistry, this behavior points to factors other than charge migration as determinants of genomic DNA oxidation.
- Subjects
DNA; IONIZATION (Atomic physics); NUCLEOTIDE sequence; OXIDIZING agents; CARBONATES
- Publication
Nature Chemical Biology, 2006, Vol 2, Issue 7, p365
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio796