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- Title
New Enzyme-Inhibitory Triterpenoid from Marine Macro Brown Alga Padina boergesenii Allender & Kraft.
- Authors
Ali, Liaqat; Khan, Abdul Latif; Al-Broumi, Muhammad; Al-Harrasi, Rashid; Al-Kharusi, Lubna; Hussain, Javid; Al-Harrasi, Ahmed
- Abstract
In continuation to our study of the chemical and biological potential of the secondary metabolites isolated from Omani seaweeds, we investigated a marine brown alga, Padina boergesenii. The phytochemical investigation resulted in the isolation of a new secondary metabolite, padinolic acid (1), along with some other semi-pure fractions and sub-fractions. The planar structure was confirmed through MS and NMR (1D and 2D) spectral data. The NOESY experiments coupled with the biogenetic consideration were helpful in assigning the stereochemistry in the molecule. Compound 1 was subjected to enzyme inhibition studies using urease, lipid peroxidase, and alpha-glucosidase enzymes. Compound 1 showed low to moderate α-glucosidase and urease enzyme inhibition, respectively, and moderate anti-lipid peroxidation activities. The current study indicates the potential of this seaweed and provides the basis for further investigation.
- Subjects
ENZYME inhibitors; TRITERPENOIDS; BROWN algae; ALGAL metabolites; MARINE algae; ALGAL enzymes
- Publication
Marine Drugs, 2017, Vol 15, Issue 1, p19
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md15010019