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- Title
Smart nanoplatform for sequential drug release and enhanced chemo-thermal effect of dual drug loaded gold nanorod vesicles for cancer therapy.
- Authors
Zhu, Falian; Tan, Guozhu; Zhong, Yingtao; Jiang, Yaodong; Cai, Lulu; Yu, Zhiqiang; Liu, Shuwen; Ren, Fei
- Abstract
Background: The combination of multiple chemotherapeutics has been used in the clinic for enhanced cancer chemotherapy, however, frequent relapse, chemo-resistance and side effects remains therapeutic hurdles. Thus, the development of co-delivery system with enhanced targeting and synergistic different modal treatments has been proposed as promising strategies for intensive improvement of the therapeutic outcomes. Results: We fabricated a nanocarrier based on gold nanorods (Au NRs), cRGD peptide-modified and multi-stimuli-responsive paclitaxel (PTX) and curcumin (CUR) release for synergistic anticancer effect and chemo-photothermal therapy (PTX/CUR/Au NRs@cRGD). The specific banding of cRGD to αvβ3 integrin receptor on the tumor cell surfaces facilitated the endocytosis of PTX/CUR/Au NRs@cRGD, and the near-infrared ray (NIR) further enhanced the drug release and chemotherapeutical efficiency. Compared to single drug, single model treatment or undecorated-PTX/CUR/Au NRs, the PTX/CUR/Au NRs@cRGD with a mild NIR showed significantly enhanced apoptosis and S phase arrest in three cancer cell lines in vitro, and improved drug accumulation in tumor sites as well as tumor growth inhibition in vivo. Conclusions: The tumor targeted chemo-photothermal therapy with the synergistic effect of dual drugs provided a versatile strategy for precise cancer therapy.
- Subjects
ANTINEOPLASTIC agents; NANORODS; CANCER treatment; APOPTOSIS; CANCER chemotherapy; CURCUMIN
- Publication
Journal of Nanobiotechnology, 2019, Vol 17, Issue 1, pN.PAG
- ISSN
1477-3155
- Publication type
Article
- DOI
10.1186/s12951-019-0473-3