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- Title
The association of Val109Asp polymorphic marker of intelectin 1 gene with abdominal obesity in Kyrgyz population.
- Authors
Isakova, Jainagul; Talaibekova, Elnura; Vinnikov, Denis; Aldasheva, Nazira; Mirrakhimov, Erkin; Aldashev, Almaz
- Abstract
Background: The aim of this study was to quantify the association of Val109Asp polymorphism of intelectin 1 (<italic>ITLN1</italic>) gene with the abdominal obesity (AO) in Kyrgyz population. Methods: Patients admitted to annual screening at a local outpatient facility were enrolled or this study. We genotyped 297 nonrelated adults of Kyrgyz ethnicity, of whom 127 were AO patients, including 46 men and 81 women with the mean age 53.2 ± 7.1 years, and 170 non-obese controls, including 61 men and 109 women with the mean age 52.0 ± 9.0 years. AO was defined as having waist circumferences ≥ 102 cm in men and ≥ 88 cm in women. We used PCR-RFLP method to define Val109Asp polymorphism of <italic>ITLN1</italic> gene. Results: Asp109Asp, Asp109Val and Val109Val genotypes were found in 48%, 40%, and 12% of AO patients respectively, and in 53%, 43%, and 4% of controls, whereas Val109Val homozygous genotype of <italic>ITLN1</italic> gene Val109Asp polymorphic marker was significantly more prevalent in AO patients. In Kyrgyz population, Val109Val genotype of <italic>ITLN1</italic> gene increased the risk of AO (odds ratio (OR) 3.12, 95% CI 1.23–7.90). Asp109Asp homozygous genotype, on opposite, was not associated with this condition (OR 0.82, 95% CI 0.53–1.30). Finally, the allelic variants of Val109Asp polymorphism of <italic>ITLN1</italic> gene were not associated with AO. Conclusion: Significant increase in the frequency of Val109Val genotype of <italic>ITLN1</italic> gene in AO patients may be indicative of some potential role of <italic>ITLN1</italic> gene in molding genetic predisposition to AO in the Kyrgyz. This requires further elaboration in the future studies.
- Subjects
KYRGYZSTAN; ADIPOKINES; OBESITY; CONFIDENCE intervals; GENETIC polymorphisms; RISK assessment; GENETIC markers; GENOTYPES; DISEASE susceptibility; KYRGYZ; POLYMERASE chain reaction; ODDS ratio
- Publication
BMC Endocrine Disorders, 2018, Vol 18, p1
- ISSN
1472-6823
- Publication type
Article
- DOI
10.1186/s12902-018-0242-6