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- Title
A serum B-lymphocyte activation signature is a key distinguishing feature of the immune response in sarcoidosis compared to tuberculosis.
- Authors
Putera, Ikhwanuliman; Schrijver, Benjamin; Kolijn, P. Martijn; van Stigt, Astrid C.; ten Berge, Josianne C. E. M.; IJspeert, Hanna; Nagtzaam, Nicole M. A.; Swagemakers, Sigrid M. A.; van Laar, Jan A. M.; Agrawal, Rupesh; Rombach, Saskia M.; van Hagen, P. Martin; La Distia Nora, Rina; Dik, Willem A.
- Abstract
Sarcoidosis and tuberculosis (TB) are two granulomatous diseases that often share overlapping clinical features, including uveitis. We measured 368 inflammation-related proteins in serum in both diseases, with and without uveitis from two distinct geographically separated cohorts: sarcoidosis from the Netherlands and TB from Indonesia. A total of 192 and 102 differentially expressed proteins were found in sarcoidosis and active pulmonary TB compared to their geographical healthy controls, respectively. While substantial overlap exists in the immune-related pathways involved in both diseases, activation of B cell activating factor (BAFF) signaling and proliferation-inducing ligand (APRIL) mediated signaling pathways was specifically associated with sarcoidosis. We identified a B-lymphocyte activation signature consisting of BAFF, TNFRSF13B/TACI, TRAF2, IKBKG, MAPK9, NFATC1, and DAPP1 that was associated with sarcoidosis, regardless of the presence of uveitis. In summary, a difference in B-lymphocyte activation is a key discriminative immunological feature between sarcoidosis/ocular sarcoidosis (OS) and TB/ocular TB (OTB). Sarcoidosis patients exhibit higher level of serum B cell activation signature compared to tuberculosis, regardless of uveitis manifestation.
- Subjects
BLOOD proteins; SARCOIDOSIS; CELLULAR signal transduction; UVEITIS; TUBERCULOSIS
- Publication
Communications Biology, 2024, Vol 7, Issue 1, p1
- ISSN
2399-3642
- Publication type
Article
- DOI
10.1038/s42003-024-06822-1