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- Title
Exploring Cognitive Changes in High-Risk Cardiac Patients Receiving Dexmedetomidine and Evaluating the Correlation between Different Cognitive Tools: A Cohort Study.
- Authors
Abu Yazit, Noor Anisah; Juliana, Norsham; Hafidz, Kamilah Muhammad; Shuhada Abd Aziz, Nur Adilah; Maluin, Sofwatul Mokhtarah; Azmani, Sahar; Mohd Fahmi Teng, Nur Islami; Das, Srijit; Kadiman, Suhaini
- Abstract
Background: Mini-mental State Examination (MMSE) is widely accepted clinically for postoperative cognitive dysfunction (POCD) assessment. This study aims to investigate the post-operative cognitive changes among high-risk cardiothoracic patients and establish a standardised approach to post-surgery cognitive assessment. Methods: This is a prospective cohort study, where cognitive assessments were done 1-day before surgery, at discharge, and during 6 weeks of follow-up. Sample size calculation, accounting for an estimated 20% dropout rate, determined a minimum of 170 subjects were required for the study. Reduction of MMSE score of more than 2.5 was considered as having POCD. Score differences between groups were analysed using T-test and analysis of variance (ANOVA), while consistency between tools was analysed using correlation and regression. Results: A total of 188 patients completed the study, with a POCD prevalence of 20.2% and 6.9% at discharge and at the 6 week follow up, respectively. All cognitive tools show a significant difference between preoperative and postoperative scores. All tests show a significant moderate correlation with MMSE. Conclusions: In conclusion, it is imperative to employ a battery of cognitive assessments to evaluate cognitive changes comprehensively.
- Publication
Reviews in Cardiovascular Medicine, 2024, Vol 25, Issue 8, p1
- ISSN
1530-6550
- Publication type
Article
- DOI
10.31083/j.rcm2508273