We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synchronous Epidermodysplasia Verruciformis and Intraepithelial Lesion of the Vulva Is Caused by Coinfection With Alpha-Human Papillomavirus and Beta-Human Papillomavirus Genotypes and Facilitated by Mutations in Cell-Mediated Immunity Genes.
- Authors
Ribeiro, Renan Ribeiro; Sung, C. James; Quddus, M. Ruhul
- Abstract
Context.--There have been exceedingly few reports of epidermodysplasia verruciformis (EV) or EV-like lesions in the vulva. We describe the first observation of vulvar lesions displaying synchronous EV-like histology and conventional high-grade squamous intraepithelial lesion (HSIL), a finding hitherto unreported in medical literature. Objectives.--To describe this novel vulvar lesion with hybrid features of HSIL and EV, attempt to confirm the hypothesis of coinfection with a and b human papillomavirus (a-HPV and b-HPV) genotypes, and describe relevant underlying genetic mutations. Design.--Cases were retrospectively selected from our institutional archive. Detailed review of clinical information, histologic examination, and whole genome sequencing (WGS) were performed. Results.--Five samples from 4 different patients were included. Three of 4 patients had a history of either iatrogenic immune suppression or prior immune deficiency, and all 3 featured classic HSIL and EV changes within the same lesion. One patient had no history of immune disorders, presented with EV-like changes and multinucleated atypia of the vulva, and was the sole patient without conventional HSIL. By WGS, several uniquely mappable reads pointed toward infection with multiple HPV genotypes, including both a-HPVs and b-HPVs. Mutations in genes implicated in cell-mediated immunity, such as DOCK8, CARMIL2, MST1, and others, were also found. Conclusions.--We provide the first description of vulvar lesions harboring simultaneous HSIL and EV features in the English-language literature, a phenomenon explained by coinfection with a-HPV and b-HPV genotypes. The finding of EV-like changes in a vulvar specimen should prompt assessment of the patient's immune status.
- Subjects
VULVAR diseases; CERVICAL intraepithelial neoplasia; PAPILLOMAVIRUS diseases; IMMUNOLOGICAL tolerance; GENETIC markers; POLYMERASE chain reaction; RETROSPECTIVE studies; IMMUNOHISTOCHEMISTRY; BIOINFORMATICS; KERATINOCYTES; MEDICAL records; ACQUISITION of data; GENITAL warts; GENETIC mutation; VULVA; CASE studies; STAINS &; staining (Microscopy); MIXED infections; GENOTYPES; IMMUNITY; SEQUENCE analysis
- Publication
Archives of Pathology & Laboratory Medicine, 2024, Vol 148, Issue 9, p1014
- ISSN
0003-9985
- Publication type
Article
- DOI
10.5858/arpa.2023-0193-OA